Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression.

Immune checkpoint blockade with therapeutic anti-cytotoxic T lymphocyte-associated antigen (CTLA)-4 (Ipilimumab) and anti-programmed death (PD)-1 (Nivolumab and Pembrolizumab) antibodies alone or in combination has shown remarkable efficacy in multiple cancer types, concomitant with immune-related adverse events, including arthralgia and inflammato

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Intra-Day Dynamic Network Reconfiguration Based on Probability Analysis Considering the Deployment of Remote Control Switches

With the continuous development of renewable distributed generation (DG) in distribution network, the effective integration of DGs to make system operation safe and economic has become a major concern.Dynamic network reconfiguration, which relies on the remote control switches, is being considered as an efficient method to solve the above problem.A

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Exploring Effective Reading Strategies: Enhancing Text Comprehension and Pedagogical Approaches in Diverse Learning Settings

Abstract: This research explores the intricate realm of effective reading strategies seeking to understand the text better and pedagogical approaches across diverse learning settings.The research problem identifies complex efficacy in the diversity of reading strategies.Methodologically, it attempts to Baggies explore and explain contextual nuances

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